Ozari vs Sesame for Weight Loss: An Honest Comparison for 2026

If you're exploring GLP-1 medications for weight loss, you've probably come across both Ozari Health and Sesame. Both platforms promise convenient access to weight loss treatments, but they work quite differently. Understanding these differences can help you make the right choice for your health journey and budget.

Let's take an honest look at how these two services compare, what they offer, and which might be the better fit for your needs.

What Is Ozari Health?

Ozari Health is a telehealth platform specifically designed for weight loss through GLP-1 medications. For $99 per month, you get access to compounded semaglutide or tirzepatide, prescribed by licensed physicians who specialize in metabolic health.

The service includes your medication, ongoing medical oversight, and support throughout your weight loss journey. Everything is managed online, with medications shipped directly to your door. It's a subscription model designed to make GLP-1 therapy straightforward and affordable.

What Is Sesame?

Sesame operates as a healthcare marketplace that connects patients with individual providers offering various services, including weight loss consultations. Unlike Ozari's all-inclusive model, Sesame works more like a booking platform where you pay separately for consultations, prescriptions, and medications.

Providers on Sesame set their own prices and protocols. You might find a doctor offering a weight loss consultation for $29 or $49, but that's just the starting point. Prescription costs and medication are separate expenses that can vary significantly.

Comparing Costs: The Real Numbers

This is where things get interesting, and why many people feel confused when comparing these services.

Ozari's Transparent Pricing

With Ozari, you pay $99 per month. This includes your medical consultation, prescription, compounded GLP-1 medication, and ongoing care. There are no hidden fees or surprise charges. You know exactly what you're paying each month.

Sesame's Variable Costs

Sesame's pricing is harder to predict. You might pay $29-49 for an initial consultation, but then you need to fill your prescription elsewhere. If you're prescribed brand-name Wegovy or Ozempic, you could be looking at $1,000+ per month without insurance coverage.

Some providers on Sesame may offer compounded medications, but you'll typically pay separately for the consultation and the prescription. When you add everything up, monthly costs can easily exceed $200-300 or more, depending on which provider you choose and what they prescribe.

Medication Access and Options

The type of medication you can access differs between platforms.

Ozari focuses on compounded semaglutide and tirzepatide. These are the same active ingredients found in brand-name medications like Wegovy, Ozempic, Mounjaro, and Zepbound, but compounded by FDA-registered pharmacies at a fraction of the cost. Compounding is legal and widely used when brand-name drugs are in shortage or cost-prohibitive.

Sesame providers may prescribe brand-name medications, compounded options, or other weight loss treatments depending on the individual practitioner. Because Sesame is a marketplace rather than a direct provider, your experience will vary based on which doctor you book with.

The Support and Continuity Factor

Weight loss is a journey, not a one-time transaction. The level of ongoing support matters tremendously.

Ozari provides continuous care through its clinical team. You're not just getting a prescription and being sent on your way. The physicians at Ozari monitor your progress, adjust dosing as needed, and are available if you have questions or concerns. This continuity is built into the monthly fee.

With Sesame, support depends entirely on the provider you choose. Some may offer excellent follow-up care, while others may require you to book and pay for additional appointments each time you need guidance. There's less standardization in the experience.

Gender Considerations in Weight Loss

Women often experience different weight loss patterns on GLP-1 medications compared to men, particularly around hormonal fluctuations during menstrual cycles or perimenopause. Having a care team that understands these nuances and can adjust treatment accordingly makes a meaningful difference. Both platforms can accommodate these needs, but Ozari's specialized focus on metabolic health means their physicians work with these patterns daily.

Convenience and Simplicity

Both services offer telehealth convenience, but the user experience differs.

Ozari streamlines everything into one simple subscription. You complete an online assessment, connect with a physician, and receive your medication by mail. Refills are automatic, and dosage adjustments happen as part of your ongoing care.

Sesame requires more navigation on your part. You browse providers, book appointments, manage prescriptions separately, and coordinate your own medication fulfillment. For some people, this flexibility is appealing. For others, it adds unnecessary complexity to an already challenging process.

Who Should Choose Which Service?

Sesame might work well if you want to browse multiple providers, prefer paying per appointment rather than subscribing, or already have insurance coverage that makes brand-name medications affordable.

Ozari is typically the better choice if you want predictable monthly costs, prefer an all-in-one solution, value specialized weight loss expertise, or need affordable access to GLP-1 medications without insurance hassles.

Many people find that Ozari's transparent pricing and comprehensive care model removes the guesswork and stress from accessing these powerful medications.

From the Ozari Care Team

When starting GLP-1 therapy, consistency matters more than perfection. We see the best results in patients who stay on their prescribed dosing schedule and communicate openly about side effects rather than stopping medication abruptly. Remember that mild nausea in the first few weeks is normal and usually improves—don't let it derail your progress before the medication has a chance to work.

At Ozari Health, we offer compounded Semaglutide and Tirzepatide starting at $99/month, prescribed by licensed physicians and shipped to your door. Learn more at ozarihealth.com.

Medically reviewed by the Ozari Clinical Care Team, licensed physicians specializing in metabolic health and GLP-1 therapy. Last reviewed: April 25, 2026