Ozari vs Sesame for Weight Loss: An Honest Comparison

If you're researching GLP-1 medications for weight loss, you've likely come across both Ozari Health and Sesame. Both platforms promise convenient access to prescription weight loss medications, but they operate quite differently. Understanding these differences can help you choose the option that best fits your health goals, budget, and the level of support you need on your weight loss journey.

What Is Ozari Health?

Ozari Health is a telehealth platform specializing exclusively in GLP-1 weight loss medications. We focus on compounded semaglutide and tirzepatide, prescribed by licensed physicians who understand metabolic health and weight management. Our model is straightforward: $99 per month, with your medication prescribed and shipped directly to your door.

Because we specialize in weight loss, our entire care team is trained specifically in GLP-1 therapy, side effect management, and the unique challenges that come with weight loss journeys.

What Is Sesame?

Sesame is a healthcare marketplace that connects patients with doctors for various services, including weight loss consultations. Think of it as a platform where independent providers list their services. You can book appointments for weight loss, primary care, mental health, and many other health needs.

For weight loss specifically, Sesame offers access to providers who can prescribe medications like Ozempic, Wegovy, Mounjaro, and sometimes compounded versions. The experience can vary significantly depending on which provider you choose.

Pricing Comparison

Ozari Health Pricing

Our pricing is transparent and all-inclusive. At $99 per month, you get your physician consultation, prescription, compounded medication, and ongoing support. There are no hidden consultation fees, no surprise charges, and no separate pharmacy bills to navigate.

Sesame Pricing

Sesame's pricing works differently. You typically pay for the doctor consultation separately, which can range from $29 to $99 or more depending on the provider. Then, you receive a prescription that you'll need to fill separately, either through Sesame's pharmacy partner or your own pharmacy.

If you're getting brand-name medications like Wegovy or Mounjaro without insurance coverage, these can cost $1,000 or more per month. Compounded options through Sesame may be available at lower prices, but the total cost including consultation fees often varies significantly.

Medication Options

What Ozari Offers

We focus on compounded semaglutide and tirzepatide. These are the same active ingredients found in brand-name medications like Ozempic, Wegovy, Mounjaro, and Zepbound, but they're prepared by specialized compounding pharmacies.

Compounded medications allow us to offer flexible dosing and keep costs significantly lower while maintaining quality and effectiveness. All our compounded medications come from FDA-registered 503B facilities that meet strict quality standards.

What Sesame Offers

Through Sesame, providers may prescribe brand-name GLP-1 medications or compounded versions, depending on the individual provider's preferences and your specific situation. The medication you ultimately receive depends on which doctor you see, what they're comfortable prescribing, and what your insurance covers.

This flexibility can be an advantage if you specifically want a brand-name medication, but it can also make it harder to predict your final costs upfront.

The Care Experience

Doctor Involvement and Follow-Up

At Ozari, you're matched with a physician who specializes in metabolic health and weight management. Because we focus exclusively on GLP-1 therapy, our doctors see hundreds of patients on these medications and understand the nuances of dosing, side effects, and what to expect at each stage.

We provide ongoing access to our care team for questions and support throughout your treatment. Adjustments to your medication can be made based on your response and any side effects you experience.

With Sesame, you book individual appointments with providers. Some patients appreciate being able to choose their specific doctor, but the level of specialized weight loss expertise and ongoing support varies. Follow-up care typically requires booking and paying for additional appointments.

Support Beyond the Prescription

Weight loss is about more than just medication. At Ozari, we provide educational resources, guidance on nutrition and lifestyle factors, and support for managing common side effects like nausea or constipation.

Sesame focuses primarily on connecting you with a provider for the prescription itself. Additional support services depend on the individual provider you select and may come with additional costs.

Gender Considerations in GLP-1 Treatment

While GLP-1 medications work effectively for both men and women, there are some differences worth noting. Women often experience slightly different side effect profiles, particularly related to nausea, and may need more gradual dose adjustments. Hormonal factors, including menstrual cycles and menopause, can also influence weight loss patterns.

Men typically lose weight slightly faster initially, though long-term results tend to even out. At Ozari, our physicians take these gender-specific factors into account when developing your treatment plan and adjusting your dosage.

Which Option Is Right for You?

If you value predictable pricing, specialized expertise in GLP-1 therapy, and ongoing support included in one monthly fee, Ozari may be the better fit. Our model works especially well for people who want a streamlined experience focused specifically on weight loss.

Sesame might appeal to you if you prefer choosing your own provider from a marketplace, want the option for brand-name medications through insurance, or are looking for a platform that handles multiple health needs beyond weight loss.

Both platforms offer legitimate access to weight loss medications. The best choice depends on your personal preferences, budget, and how much specialized support you want throughout your weight loss journey.

From the Ozari Care Team

One of the most common mistakes we see is patients switching between multiple providers or platforms during their GLP-1 journey, which disrupts continuity of care and makes it harder to optimize dosing. Consistency matters with these medications. Whether you choose Ozari or another platform, commit to working with the same medical team for at least three to six months so they can properly adjust your treatment based on your individual response.

At Ozari Health, we offer compounded semaglutide and tirzepatide starting at $99/month, prescribed by licensed physicians and shipped to your door. Learn more at ozarihealth.com.

Medically reviewed by the Ozari Clinical Care Team, licensed physicians specializing in metabolic health and GLP-1 therapy. Last reviewed: April 26, 2026